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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDM4
All Species:
27.27
Human Site:
T222
Identified Species:
66.67
UniProt:
O15151
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15151
NP_002384.2
490
54864
T222
N
G
S
T
D
L
Q
T
N
Q
D
V
G
T
A
Chimpanzee
Pan troglodytes
XP_514127
490
54873
T222
N
G
S
T
D
L
Q
T
N
Q
D
V
G
T
A
Rhesus Macaque
Macaca mulatta
XP_001097583
479
53952
G211
N
Y
T
P
R
S
N
G
S
T
D
L
Q
T
N
Dog
Lupus familis
XP_536098
519
58173
T249
N
G
S
T
D
L
Q
T
N
Q
D
I
G
T
A
Cat
Felis silvestris
Mouse
Mus musculus
O35618
489
54974
T222
N
G
S
T
D
L
Q
T
N
Q
D
I
G
T
A
Rat
Rattus norvegicus
Q5XIN1
490
55202
T223
N
G
S
T
D
L
Q
T
N
Q
D
I
G
T
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507004
516
57467
T247
N
G
S
T
D
L
Q
T
N
Q
D
I
D
T
A
Chicken
Gallus gallus
XP_417957
481
54617
T219
K
S
R
S
N
G
S
T
D
I
Q
T
N
Q
D
Frog
Xenopus laevis
Q7ZYI3
475
53387
S214
I
G
S
T
D
I
P
S
N
Q
D
I
D
T
A
Zebra Danio
Brachydanio rerio
Q7ZUW7
496
55223
P223
I
H
T
N
Q
L
S
P
G
Q
D
E
D
T
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
92.8
88.8
N.A.
84
84.2
N.A.
68.5
59.7
47.1
47.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
94.4
90.7
N.A.
90.8
90.1
N.A.
78.6
73
65.9
62.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
20
93.3
N.A.
93.3
93.3
N.A.
86.6
6.6
60
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
40
100
N.A.
100
100
N.A.
93.3
26.6
80
40
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
80
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
70
0
0
0
10
0
90
0
30
0
10
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
70
0
0
0
10
0
10
10
0
0
0
50
0
0
% G
% His:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
20
0
0
0
0
10
0
0
0
10
0
50
0
0
0
% I
% Lys:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
70
0
0
0
0
0
10
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
70
0
0
10
10
0
10
0
70
0
0
0
10
0
10
% N
% Pro:
0
0
0
10
0
0
10
10
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
10
0
60
0
0
80
10
0
10
10
0
% Q
% Arg:
0
0
10
0
10
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
10
70
10
0
10
20
10
10
0
0
0
0
0
0
% S
% Thr:
0
0
20
70
0
0
0
70
0
10
0
10
0
90
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
20
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _